Chetan Seshadri, MD | Allergy and Infectious Diseases

Adjunct Associate Professor

Global Health

Associate Professor

Medicine - Division of Allergy & Infectious Diseases

Adjunct Associate Professor

Lab Medicine and Pathology

Affiliate Investigator

Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center

Sites of Practice:

Harborview Medical Center

University of Washington Medical Center

Faculty Information

Biography

Dr. Seshadri's research focuses on the human immune response to Mycobacterium tuberculosis, the bacteria responsible for tuberculosis. By better understanding what factors are responsible for protective immunity, he hopes to contribute to ongoing efforts to develop an effective vaccine. Specifically, his work addresses two questions:

What is the role of T-cells that respond to lipids and small molecules produced by bacteria?
Why do some people fail to convert their tuberculin skin tests despite frequent and close contact with tuberculosis patients?

Education & Training:

New Jersey Medical School

Newark NJ

2001

Internship and Residency in Internal Medicine

Duke University Medical Center

Durham NC

2001-2004

Clinical and Research Fellow in Infectious Diseases

Massachusetts General Hospital

Boston MA

2005-2009

Senior Fellowship in Infectious Diseases

University of Washington School of Medicine

Seattle WA

2009-2010

Honors:

Alpha Omega Alpha (AOA) Medical Honors Society, UMDNJ -New Jersey Medical School

2000

Infectious Disease Society of Washington Fellow Research Award and Presentation

2010

Chair of Medicine Scholars Award

2013

American Society of Clinical Investigation –Young Physician Scientist Award

2014

Contact

Email:

seshadri@uw.edu

Phone:

(206) 543-6709

Mailing Address:

750 Republican St.

Box 358071

Seattle, WA 98109

Research & Clinical Interests

Research Interests:

Tuberculosis
Immunology

Clinical Interests:

General medicine
General infectious diseases
Tuberculosis

Publications

PubMed:

PubMed Bibliography

Publications:

Yu KK, Fischinger S, Smith MT, Atyeo C, Cizmeci D, Wolf CR, Layton ED, Logue JK, Aguilar MS, Shuey K, Loos C, Yu J, Franko N, Choi RY, Wald A, Barouch DH, Koelle DM, Lauffenburger D, Chu HY, Alter G, Seshadri C. Comorbid illnesses are associated with altered adaptive immune responses to SARS-CoV-2. JCI Insight. 2021 Mar 22;6(6):e146242. doi: 10.1172/jci.insight.146242. PMID: 33621211

Layton ED, Barman S, Wilburn DB, Yu KKQ, Smith MT, Altman JD, Scriba TJ, Tahiri N, Minnaard AJ, Roederer M, Seder RA, Darrah PA, Seshadri C. T Cells Specific for a Mycobacterial Glycolipid Expand after Intravenous Bacillus Calmette-Guérin Vaccination. J Immunol. 2021 Mar 15;206(6):1240-1250. doi: 10.4049/jimmunol.2001065. Epub 2021 Feb 3. PMID: 33536255

James CA, Seshadri C. T Cell Responses to Mycobacterial Glycolipids: On the Spectrum of "Innateness". Front Immunol. 2020 Feb 11;11:170. doi: 10.3389/fimmu.2020.00170. eCollection 2020. PMID: 32117300