Chetan Seshadri, MD
Associate Professor
Department of Medicine, Division of Allergy & Infectious Diseases
Adjunct Professor
Department of Pathology
Affiliate Investigator
Vaccine & Infectious Diseases Division (VIDD), Fred Hutchinson Cancer Research Center
Sites of Practice: 
Harborview Medical Center
University of Washington Medical Center

Faculty Information

Biography

Dr. Seshadri's research focuses on the human immune response to Mycobacterium tuberculosis, the bacteria responsible for tuberculosis. By better understanding what factors are responsible for protective immunity, he hopes to contribute to ongoing efforts to develop an effective vaccine. Specifically, his work addresses two questions:

  • What is the role of T-cells that respond to lipids and small molecules produced by bacteria?
  • Why do some people fail to convert their tuberculin skin tests despite frequent and close contact with tuberculosis patients?
Education & Training: 
MD
New Jersey Medical School
Newark NJ
2001
Internship and Residency in Internal Medicine
Duke University Medical Center
Durham NC
2001-2004
Clinical and Research Fellow in Infectious Diseases
Massachusetts General Hospital
Boston MA
2005-2009
Senior Fellowship in Infectious Diseases
University of Washington School of Medicine
Seattle WA
2009-2010
Honors: 
Alpha Omega Alpha (AOA) Medical Honors Society, UMDNJ -New Jersey Medical School
2000
Infectious Disease Society of Washington Fellow Research Award and Presentation
2010
Chair of Medicine Scholars Award
2013
American Society of Clinical Investigation –Young Physician Scientist Award
2014
Contact
Phone: 
(206) 543-6709
Mailing Address: 

750 Republican St.

Box 358061

Seattle, WA 98109

Research & Clinical Interests
Research Interests: 
  • Tuberculosis
  • Immunology
Clinical Interests: 
  • General medicine
  • General infectious diseases
  • Tuberculosis
Publications
Publications: 

Seshadri C, Thuong NT, Yen NT, Bang ND, Chau TT, Thwaites GE, Dunstan SJ, Hawn TR. A polymorphism in human CD1A is associated with susceptibility totuberculosis. Genes Immun. 2014 Apr-May; 15(3):195-8.Epub 2014 Feb 6.
• PubMed Abstract

Seshadri C, Shenoy M, Wells RD, Hensley-McBain T, Andersen-Nissen E, McElrath MJ, Cheng TY, Moody DB, Hawn TR. Human CD1a deficiency is common and genetically regulated. J Immunol. 2013 Aug 15; 191(4):1586-93. Epub 2013 Jul 15.
• PubMed Abstract

Seshadri C, Turner MT, Lewinsohn DM, Moody DB, Van Rhijn I. Lipoproteins are major targets of the polyclonal human T cell response to Mycobacterium tuberculosis. J Immunol. 2013 Jan 1; 190(1):278-84. Epub 2012 Nov 28.
• PubMed Abstract

Kasmar AG, van Rhijn I, Cheng TY, Turner M, Seshadri C, Schiefner A, Kalathur RC, Annand JW, de Jong A, Shires J, Leon L, Brenner M, Wilson IA, Altman JD, Moody DB. CD1b tetramers bind aß T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans. J Exp Med. 2011 Aug 29; 208(9):1741-7. Epub 2011 Aug 1.
• PubMed Abstract

Drage MG, Tsai HC, Pecora ND, Cheng TY, Arida AR, Shukla S, Rojas RE, Seshadri C, Moody DB, Boom WH, Sacchettini JC, Harding CV. Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2. Nat Struct Mol Biol. 2010 Sep; 17(9):1088-95. Epub 2010 Aug 8.
• PubMed Abstract