Chetan Seshadri, MD
Adjunct Associate Professor
Global Health
Associate Professor
Medicine - Division of Allergy & Infectious Diseases
Adjunct Associate Professor
Lab Medicine and Pathology
Affiliate Investigator
Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center
Sites of Practice: 
Harborview Medical Center
University of Washington Medical Center

Faculty Information


Dr. Seshadri's research focuses on the human immune response to Mycobacterium tuberculosis, the bacteria responsible for tuberculosis. By better understanding what factors are responsible for protective immunity, he hopes to contribute to ongoing efforts to develop an effective vaccine. Specifically, his work addresses two questions:

  • What is the role of T-cells that respond to lipids and small molecules produced by bacteria?
  • Why do some people fail to convert their tuberculin skin tests despite frequent and close contact with tuberculosis patients?
Education & Training: 
New Jersey Medical School
Newark NJ
Internship and Residency in Internal Medicine
Duke University Medical Center
Durham NC
Clinical and Research Fellow in Infectious Diseases
Massachusetts General Hospital
Boston MA
Senior Fellowship in Infectious Diseases
University of Washington School of Medicine
Seattle WA
Alpha Omega Alpha (AOA) Medical Honors Society, UMDNJ -New Jersey Medical School
Infectious Disease Society of Washington Fellow Research Award and Presentation
Chair of Medicine Scholars Award
American Society of Clinical Investigation –Young Physician Scientist Award
(206) 543-6709
Mailing Address: 

750 Republican St.

Box 358071

Seattle, WA 98109

Research & Clinical Interests
Research Interests: 
  • Tuberculosis
  • Immunology
Clinical Interests: 
  • General medicine
  • General infectious diseases
  • Tuberculosis

Yu KK, Fischinger S, Smith MT, Atyeo C, Cizmeci D, Wolf CR, Layton ED, Logue JK, Aguilar MS, Shuey K, Loos C, Yu J, Franko N, Choi RY, Wald A, Barouch DH, Koelle DM, Lauffenburger D, Chu HY, Alter G, Seshadri C. Comorbid illnesses are associated with altered adaptive immune responses to SARS-CoV-2. JCI Insight. 2021 Mar 22;6(6):e146242. doi: 10.1172/jci.insight.146242. PMID: 33621211 

Layton ED, Barman S, Wilburn DB, Yu KKQ, Smith MT, Altman JD, Scriba TJ, Tahiri N, Minnaard AJ, Roederer M, Seder RA, Darrah PA, Seshadri C. T Cells Specific for a Mycobacterial Glycolipid Expand after Intravenous Bacillus Calmette-Guérin Vaccination. J Immunol. 2021 Mar 15;206(6):1240-1250. doi: 10.4049/jimmunol.2001065. Epub 2021 Feb 3. PMID: 33536255

James CA, Seshadri C. T Cell Responses to Mycobacterial Glycolipids: On the Spectrum of "Innateness".  Front Immunol. 2020 Feb 11;11:170. doi: 10.3389/fimmu.2020.00170. eCollection 2020. PMID: 32117300