David M. Koelle, MD
Department of Medicine, Division of Allergy & Infectious Diseases
Adjunct Professor
Department of Global Health
Joint Professor
Department of Laboratory Medicine & Pathology
Affiliate Investigator
Benaroya Research Institute, Seattle, WA
Affiliate Investigator
Clinical Research Division, Fred Hutchinson Cancer Research Center
Affiliate Investigator
Vaccine & Infectious Diseases Division (VIDD), Fred Hutchinson Cancer Research Center
Attending Physician, Harborview Medical Center
Attending Physician, Virology Clinic
Sites of Practice: 
Harborview Medical Center
University of Washington Medical Center

Faculty Information


T-cell immunology is at the core of infectious diseases, cancer, and allergy. We have projects concerning herpes simplex viruses types 1 and 2, varicella zoster virus, vaccinia (the vaccine for smallpox), Merkel cell polyoma virus, and HHV-6, and a project on T cell-mediated severe drug reactions. These pathogens mostly have large genomes, so determining T-cell antigens is challenging. Our technical expertise is various molecular methods to interrogate T-cell responses to a very high level of definition. A suite of modern immunology tools such as intracellular cytokine cytometry, tetramers, T cell cloning, artificial APC, cell killing assays, transgenic TCR expression, etc. are in use to correlate immune variables with outcomes or immune responses to vaccination. HSV-1 and HSV-2 vaccine candidates have been discovered, studied in mice, and entered human trials. We perform immune monitoring for human clinical trials of candidate HSV vaccines. For Mycobacterium tuberculosis (MTB), I am responsible for the IGRA testing at our medical center, and have mentored several trainees interested in this T-cell immunology clinical test. Fellows interested in modern laboratory immunology are welcome. For papers, search Pubmed on "Koelle DM".

Education & Training: 
University of Washington
Seattle WA
Tufts-New England Medical Center
Boston, MA
Fellowship in Infectious Diseases
University of Washington
Seattle WA
Phi Beta Kappa
Alpha Omega Alpha
Fellow, Infectious Diseases Society of America (IDSA)
American Board of Internal Medicine, Infectious Diseases