David M. Koelle, MD
Professor
Department of Medicine, Division of Allergy and Infectious Diseases
Adjunct Professor
Department of Global Health
Joint Professor
Laboratory Medicine
Affiliate Investigator, Fred Hutchinson Cancer Research Center

Faculty Information

Biography

T-cell immunology is at the core of infectious diseases, cancer, and allergy. We have projects concerning herpes simplex viruses types 1 and 2, varicella zoster virus, vaccinia (the vaccine for smallpox), Merkel cell polyoma virus, and HHV-6, and a project on T cell-mediated severe drug reactions. These pathogens mostly have large genomes, so determining T-cell antigens is challenging. Our technical expertise is various molecular methods to interrogate T-cell responses to a very high level of definition. A suite of modern immunology tools such as intracellular cytokine cytometry, tetramers, T cell cloning, artificial APC, cell killing assays, transgenic TCR expression, etc. are in use to correlate immune variables with outcomes or immune responses to vaccination. HSV-1 and HSV-2 vaccine candidates have been discovered, studied in mice, and entered human trials. We perform immune monitoring for human clinical trials of candidate HSV vaccines. For Mycobacterium tuberculosis (MTB), I am responsible for the IGRA testing at our medical center, and have mentored several trainees interested in this T-cell immunology clinical test. Fellows interested in modern laboratory immunology are welcome. For papers, search Pubmed on "Koelle DM".

Education & Training: 
MD
University of Washington
Seattle WA
1985
Residency
Tufts-New England Medical Center
Boston, MA
1986-1988
Fellowship in Infectious Diseases
University of Washington
Seattle WA
1989-1992
Honors: 
Phi Beta Kappa
1979
Alpha Omega Alpha
1984
Fellow, Infectious Diseases Society of America
2009
American Board of Internal Medicine, Infectious Diseases
2013