David M. Koelle, MD
Professor
Department of Medicine, Division of Allergy & Infectious Diseases
Adjunct Professor
Department of Global Health
Joint Professor
Department of Laboratory Medicine & Pathology
Affiliate Investigator
Benaroya Research Institute, Seattle, WA
Affiliate Investigator
Clinical Research Division, Fred Hutchinson Cancer Research Center
Affiliate Investigator
Vaccine & Infectious Diseases Division (VIDD), Fred Hutchinson Cancer Research Center
Attending Physician, Harborview Medical Center
Attending Physician, Virology Clinic
Sites of Practice: 
Harborview Medical Center
University of Washington Medical Center

Faculty Information

Biography

T-cell immunology is at the core of infectious diseases, cancer, and allergy. We have projects concerning herpes simplex viruses types 1 and 2, varicella zoster virus, vaccinia (the vaccine for smallpox), Merkel cell polyoma virus, and HHV-6, and a project on T cell-mediated severe drug reactions. These pathogens mostly have large genomes, so determining T-cell antigens is challenging. Our technical expertise is various molecular methods to interrogate T-cell responses to a very high level of definition. A suite of modern immunology tools such as intracellular cytokine cytometry, tetramers, T cell cloning, artificial APC, cell killing assays, transgenic TCR expression, etc. are in use to correlate immune variables with outcomes or immune responses to vaccination. HSV-1 and HSV-2 vaccine candidates have been discovered, studied in mice, and entered human trials. We perform immune monitoring for human clinical trials of candidate HSV vaccines. For Mycobacterium tuberculosis (MTB), I am responsible for the IGRA testing at our medical center, and have mentored several trainees interested in this T-cell immunology clinical test. Fellows interested in modern laboratory immunology are welcome. For papers, search Pubmed on "Koelle DM".

Education & Training: 
MD
University of Washington
Seattle WA
1985
Residency
Tufts-New England Medical Center
Boston, MA
1986-1988
Fellowship in Infectious Diseases
University of Washington
Seattle WA
1989-1992
Honors: 
Phi Beta Kappa
1979
Alpha Omega Alpha
1984
Fellow, Infectious Diseases Society of America (IDSA)
2009
American Board of Internal Medicine, Infectious Diseases
2013