Associate ProfessorDepartment of Medicine, Division of Allergy & Infectious Diseases Adjunct Associate ProfessorDepartment of Microbiology Adjunct Associate ProfessorDepartment of Global Health Related Links: Hybiske LabUW Department of MedicineUW Department of MicrobiologyUW Department of Global HealthUW Center for Emerging & Re-emerging Infectious Diseases (CERID)Faculty Information Biography The Hybiske laboratory is broadly interested in the interactions between intracellular pathogens and host cells. The lab is particularly interested in the pathways used by intracellular organisms to exit host cells. This research encompasses the underlying molecular mechanisms of these processes and the illumination of how these strategies facilitate unique interactions with the host immune system, most notably for immune evasion. A major research focus in the lab is to decipher the mechanisms by which the intracellular pathogens Chlamydia and malaria manipulate cellular function in order to exit host cells and cause infectious disease. Collectively, diseases caused by Chlamydia and malaria are the among the most devastating and widespread to plague mankind; effective intervention strategies are sorely lacking. And remarkably, these two disparate pathogens have coevolved similar mechanisms for escaping their respective host cells and disseminating within human hosts. Our ultimate goal is to leverage a thorough understanding of these pathogenic mechanisms as a new, unexplored therapeutic platform. For additional information, please visit http://www.hybiskelab.org Education & Training: PhD, Molecular and Cell BiologyUniveristy of CaliforniaBerkeley CA2003 Postdoctoral fellowUniveristy of CaliforniaBerkeley CA2003 Postdoctoral fellowUniveristy of CaliforniaSan Francisco WA2003-2005 Postdoctoral fellowUniveristy of CaliforniaBerkeley CA2005-2008 Honors: Predoctoral fellowship award, California Tobacco-Related Disease Research Program1999-2002 NIAID Young Investigator Award2010 Top Ten Reviewer for Cellular Microbiology2013 Contact Email: khybiske@uw.eduPhone: (206) 616-1549Mailing Address: 750 Republican St. Box 358061 Seattle, WA 98109-4725 Research & Clinical Interests Research Interests: The Hybiske Lab investigates the molecular mechanisms of Chlamydia pathogenesis, including sexually transmitted infections. Our ultimate goals are to identify new therapeutic targets against this major pathogen, and to contribute to our broader understanding of the pathogenic mechanisms of intracellular bacteria. Current research projects include: Mechanisms of Chlamydia exit from host cells, dissemination, and immune evasion Functional genomics for Chlamydia Virulence factor discovery for Chlamydia Proteomic discovery of novel Chlamydia-host interactions Publications PubMed: PubMed BibliographyMy NCBI: My NCBI BibliographyPublications: Chin E, Kirker K, Zuck M, James G, Hybiske K. Actin recruitment to the Chlamydia inclusion is spatiotemporally regulated by a mechanism that requires host and bacterial factors. PLoS ONE. 2012; 7(10):e46949.• PLOS One Abstract Hybiske K, Stephens RS. Exit strategies of intracellular pathogens. Nature Reviews Microbiol. 2008; 6:99-110. • PubMed Abstract Hybiske K, Stephens RS. Mechanisms of host cell exit by the intracellular bacterium Chlamydia. Proc Natl Acad Sci USA. 2007; 104:11430-11435.• PNAS Abstract Hybiske K, Stephens RS. Entry mechanisms of Chlamydia trachomatis into non-phagocytic cells. Infect Immun. 2007; 75:3925-3934.• PubMed Abstract