Kevin Hybiske, PhD
Associate Professor
Department of Medicine, Division of Allergy & Infectious Diseases
Adjunct Associate Professor
Department of Microbiology
Adjunct Associate Professor
Department of Global Health

Faculty Information

Biography

The Hybiske laboratory is broadly interested in the interactions between intracellular pathogens and host cells. The lab is particularly interested in the pathways used by intracellular organisms to exit host cells. This research encompasses the underlying molecular mechanisms of these processes and the illumination of how these strategies facilitate unique interactions with the host immune system, most notably for immune evasion. 

A major research focus in the lab is to decipher the mechanisms by which the intracellular pathogens Chlamydia and malaria manipulate cellular function in order to exit host cells and cause infectious disease. Collectively, diseases caused by Chlamydia and malaria are the among the most devastating and widespread to plague mankind; effective intervention strategies are sorely lacking. And remarkably, these two disparate pathogens have coevolved similar mechanisms for escaping their respective host cells and disseminating within human hosts. Our ultimate goal is to leverage a thorough understanding of these pathogenic mechanisms as a new, unexplored therapeutic platform.

For additional information, please visit http://www.hybiskelab.org

Education & Training: 
PhD, Molecular and Cell Biology
Univeristy of California
Berkeley CA
2003
Postdoctoral fellow
Univeristy of California
Berkeley CA
2003
Postdoctoral fellow
Univeristy of California
San Francisco WA
2003-2005
Postdoctoral fellow
Univeristy of California
Berkeley CA
2005-2008
Honors: 
Predoctoral fellowship award, California Tobacco-Related Disease Research Program
1999-2002
NIAID Young Investigator Award
2010
Top Ten Reviewer for Cellular Microbiology
2013
Contact
Phone: 
(206) 616-1549
Mailing Address: 

750 Republican St.

Box 358061

Seattle, WA 98109-4725

Research & Clinical Interests
Research Interests: 
The Hybiske Lab investigates the molecular mechanisms of Chlamydia pathogenesis, including sexually transmitted infections. Our ultimate goals are to identify new therapeutic targets against this major pathogen, and to contribute to our broader understanding of the pathogenic mechanisms of intracellular bacteria. Current research projects include:
 
  • Mechanisms of Chlamydia exit from host cells, dissemination, and immune evasion
  • Functional genomics for Chlamydia
  • Virulence factor discovery for Chlamydia
  • Proteomic discovery of novel Chlamydia-host interactions
Publications
Publications: 

Chin E, Kirker K, Zuck M, James G, Hybiske K. Actin recruitment to the Chlamydia inclusion is spatiotemporally regulated by a mechanism that requires host and bacterial factors. PLoS ONE. 2012; 7(10):e46949.
• PLOS One Abstract

Hybiske K, Stephens RS. Exit strategies of intracellular pathogens. Nature Reviews Microbiol. 2008; 6:99-110. 
• PubMed Abstract

Hybiske K, Stephens RS. Mechanisms of host cell exit by the intracellular bacterium Chlamydia. Proc Natl Acad Sci USA. 2007; 104:11430-11435.
• PNAS Abstract

Hybiske K, Stephens RS. Entry mechanisms of Chlamydia trachomatis into non-phagocytic cells. Infect Immun. 2007; 75:3925-3934.
• PubMed Abstract