Department of Medicine
The Hybiske laboratory is broadly interested in the interactions between intracellular pathogens and host cells. The lab is particularly interested in the pathways used by intracellular organisms to exit host cells. This research encompasses the underlying molecular mechanisms of these processes and the illumination of how these strategies facilitate unique interactions with the host immune system, most notably for immune evasion.
A major research focus in the lab is to decipher the mechanisms by which the intracellular pathogens Chlamydia and malaria manipulate cellular function in order to exit host cells and cause infectious disease. Collectively, diseases caused by Chlamydia and malaria are the among the most devastating and widespread to plague mankind; effective intervention strategies are sorely lacking. And remarkably, these two disparate pathogens have coevolved similar mechanisms for escaping their respective host cells and disseminating within human hosts. Our ultimate goal is to leverage a thorough understanding of these pathogenic mechanisms as a new, unexplored therapeutic platform.
For additional information, please visit http://www.hybiskelab.org
750 Republican St.
Seattle, WA 98109-4725
Chin E, Kirker K, Zuck M, James G, Hybiske K. Actin recruitment to the Chlamydia inclusion is spatiotemporally regulated by a mechanism that requires host and bacterial factors. PLoS ONE. 2012; 7(10):e46949.• PLOS One Abstract
Hybiske K, Stephens RS. Exit strategies of intracellular pathogens. Nature Reviews Microbiol. 2008; 6:99-110. • PubMed Abstract
Hybiske K, Stephens RS. Mechanisms of host cell exit by the intracellular bacterium Chlamydia. Proc Natl Acad Sci USA. 2007; 104:11430-11435.• PNAS Abstract
Hybiske K, Stephens RS. Entry mechanisms of Chlamydia trachomatis into non-phagocytic cells. Infect Immun. 2007; 75:3925-3934.• PubMed Abstract