Sheila A. Lukehart, PhD
Professor
Medicine and Global Health
Adjunct Professor
Microbiology
Director, University of Washington STD & HIV Research Training Program
Associate Dean for Research & Graduate Education

Faculty Information

Biography

The Lukehart laboratory studies the pathogenesis of syphilis and the immune response to Treponema pallidum in humans and in animal models. Our current major interest is the 12-membered tpr gene family of T. pallidum, which is hypothesized to encode surface-exposed antigens that are major targets of the protective immune response, may be involved in immune evasion, and are promising vaccine candidates. We have demonstrated that one member of the Tpr family, TprK, undergoes antigenic variation; studies related to the immunological relevance and molecular mechanism of this variation are ongoing.  New studies are focused on TprC and TprD, which are also surface exposed, and which differ in sequence among T. pallidum strains and subspecies. The laboratory is also working to identify surface molecules that are targets of opsonization and to define the kinetics of and requirements for bactericidal activity by macrophages. Many of the projects described above involve collaborations with Drs. Arturo Centurion-Lara and Lorenzo Giacani.

Additionally, our laboratory is involved in studies of clinical aspects of syphilis and other trponematoses. With Dr. Christina Marra (Neurology), the laboratory is exploring the molecular basis for neuroinvasion, the immunologic response to T. pallidum within the CNS, and the efficacy of recommended therapy for CNS syphilis in immunocompetent and HIV-infected patients. Other ongoing studies involve the investigation of emerging macrolide resistance, application of a molecular typing method for T. pallidum to epidemiological studies of syphilis, and studies of yaws in Papua New Guinea.

Education & Training: 
PhD, Microbiology and Immunology
University of California, San Diego
San Diego, CA
1978
Senior Postdoctoral Fellow, Department of Medicine/Infectious Diseases, School of Medicine, University of Washington (King K. Holmes, M.D., Ph.D.)
University of Washington
Seattle, WA
1979-1980
Postdoctoral Research Fellow, Department of Pathology, School of Medicine, University of California, San Diego (Stewart Sell, M.D.)
University of Washington
Seattle, WA
1978-1979
Honors: 
Distinguished Career Award, American Sexually Transmitted Diseases Association
Seattle Association for Women in Science Award for Scientific Advancement
American Venereal Disease Association Achievement Award