Sylvia M. LaCourse, MD, MPH
Assistant Professor
Department of Medicine, Division of Allergy & Infectious Diseases
Assistant Professor
Department of Global Health

Faculty Information

Biography

Dr. LaCourse’s research focuses on improving TB screening and prevention in HIV-infected peripartum women and their children and has multiple ongoing research projects primarily in Kenya.

Dr. LaCourse is a GWACh (Global Women, Adolescent, and Child health) scientific lead, Kenya Research and Training Center (KRTC) faculty member, Tuberculosis Research & Training Center (TRTC) leadership committee member, and TB ECHO (Extension for Community Healthcare Outcomes) faculty. She is committed to the inclusion of children and pregnant women in HIV/TB research as an IMPAACT (International Maternal Pediatric Adolescent AIDS Clinical Trials Network) TB Scientific Committee mentored junior investigator, and International Union Against TB and Lung Disease Maternal Child Health Working Group Scientific Co-Lead.

She is an attending physician at the Madison HIV clinic and infectious diseases, general medicine, and HIV inpatient services at the University of Washington and Harborview Medical Centers.

Education & Training: 
MD
University of Louisville School of Medicine (AOA)
Louisville KY
2007
Internal Medicine/Pediatrics residency
Warren Alpert Medical School of Medicine, Brown University
Province RI
2007-2011
NIH Fogarty International Clinical Research Fellowship
UNC Project
Lilongwe, Malawi
2011-2012
Fellow
Division of Allergy and Infectious Diseases, University of Washington
Seattle WA
2012-2015
MPH Epidemiology
Global Health Track University of Washington
Seattle WA
2013-2015
Honors: 
AOA, University of Louisville, School of Medicine
2007
National Medicine/ Pediatrics Residency Association Advocacy/ Community Service Award
2009
CFAR International Pilot Project Award
2014
Firland Foundation Bridge Funding Award
2015
K23 Mentored Patient-Oriented Research Career Development Award
2016
AIDS 2016 Scholarship Award
2016
CFAR New Investigator Award
2016
Chair of Medicine Award
2018
Contact
Phone: 
(206) 616-5978
Research & Clinical Interests
Research Interests: 

My primary research interest is improving TB screening and prevention in peripartum women and children in high HIV/TB burden settings. Recent work has focused on novel non-sputum based TB diagnostics and the effect of pregnancy on LTBI screening and prevention approaches, as well as collaborating with TB immunologist to better understand the unique feature of these populations and how they may effect TB pathogenesis.

Current projects:

NIH/NIAID K23  Impact of maternal HIV on Mycobacterium tuberculosis (Mtb) infection among peripartum women and their infants (PI: LaCourse) Mentors: Grace John-Stewart (UW), Amita Gupta (Johns Hopkins)

Thrasher Foundation Preventing Mycobacterium tuberculosis infection in HIV exposed infants (Co-PI: John-Stewart & Hawn) Role: Project Director, Co-Investigator

NIH/NIAID R01 The effect of HIV exposure and infection on immunity to TB in children (PI: John-Stewart, Day)  Role: Co-Investigator

NIH/NIAID R21 NanoDisk-MS measured Mtb antigen peptides for TB diagnosis and treatment monitoring in HIV-infected children (PI: LaCourse) (Co-I Ye Hu, Arizona University BioDesign Institute)

NIH/NICHD R21 Dynamics of tuberculosis immune response in peripartum HIV-infected and HIV-uninfected women (Co-PI: LaCourse, Javeed Shah [UW DAID]) Co-I Jai Lingappa, DGH ICRC)

NIH/UW CFAR New Investigator Award (PI: LaCourse)   Oral swab analysis (OSA) for TB diagnosis in women, adolescents, and HIV-infected individuals Mentors: Grace John-Stewart (UW), Gerard Cangelosi (UW Dept of Environmental and Occupational Health)

Clinical Interests: 
  • HIV
  • TB/LTBI (including PLHIV, children, and women of childbearing potential)
  • HIV PEP in adolescents
Publications
Publications: 

Mathad JS, LaCourse SM, Gupta A. TB prevention strategies and unanswered questions for pregnant and postpartum women living with HIV: the need for improved evidence. J Int AIDS Soc. 2020; 23(3):e25481.
 

LaCourse SM, Cranmer L, Matemo D, Richardson B, Kinuthia J, John-Stewart G, Horne DJ. Active tuberculosis case finding in HIV-infected pregnant women in Kenya reveals poor performance of symptom screening and rapid diagnostic tests. JAIDS. 2016 Feb 1; 71(2):219-27.
• PubMed Abstract

Jonnalagadda S, LaCourse SM, Otieno P, Lohman-Payne B, Maleche-Obimbo E, Cranmer LM, John-Stewart GC. Incidence and correlates of tuberculosis IGRA conversion among HIV-infected postpartum women. Int J Tuberc Lung Dis. 2015 Jul; 19(7):792-8.
• PubMed Abstract

LaCourse SM, Chester FM, Matoga M, Munthali C, Nsona D, Haac B, Hoffman IF, Hosseinipour MC. Implementation and Operational Research: Implementation of Routine Counselor-Initiated Opt-Out HIV Testing on the Adult Medical Ward at Kamuzu Central Hospital, Lilongwe, Malawi. JAIDS. 2015 May 1; 69(1):e31-5.
PubMed Abstract

LaCourse SM, Chester FM, Preidis G, McCrary LM, Arscott-Mills T, Maliwichi M, James G, McCollum ED, Hosseinipour MC. Use of Xpert for the diagnosis of pulmonary tuberculosis in severely malnourished hospitalized Malawian children. Pediatr Infect Dis J. 2014 Nov; 33(11):1200-2.
• PubMed Abstract

LaCourse SM, Chester FM, Preidis G, McCrary LM, Maliwichi M, McCollum ED, Hosseinipour MC. Lay-screeners and use of WHO growth standards increase case finding of hospitalized Malawian children with severe acute malnutrition. J Trop Pediatr. 2015 Feb; 61(1):44-53.
 PubMed Abstract