Thomas R. Hawn, MD, PhD
Department of Medicine, Division of Allergy & Infectious Diseases
Sites of Practice: 
Harborview Medical Center

Faculty Information


Tom’s laboratory examines why individuals have different susceptibility to infections and whether these insights can lead to novel treatment and vaccine strategies. Studies include examining the functional and clinical significance of human variation in the innate immune system and its regulation of susceptibility to tuberculosis and other infections. His laboratory defines and characterizes the cellular function of genetic polymorphisms in innate immune response genes and the mechanisms of how they regulate susceptibility to human infection with an overall goal of elucidating novel therapeutic strategies.

UW Dept of Medicine’s Philip and Helen Fialkow Award
Burroughs Wellcome Fund Clinical Scientist Award in Translational Research
American Society of Clinical Investigation
UW Dept Medicine Housestaff Research Mentorship Award
(206) 616-4124
Mailing Address: 

750 Republican St.

Box: 358061

Seattle, WA 98109-4725

Research & Clinical Interests
Research Interests: 
  • Tuberculosis
  • Mycobacterial Diseases (Leprosy, MAC)
  • Innate Immunity
  • Pulmonary Immunity
Clinical Interests: 
  • Tuberculosis
  • Mycobacterial Diseases
  • HIV
  • General Infectious Disease

Simmons JD, Stein CM, Seshadri C, Campo M, Alter G, Fortune S, Schurr E, Wallis RS, Churchyard G, Mayanja-Kizza H, Boom WH, Hawn TR. Immunologic mechanisms of human resistance to persistent Mycobacterium tuberculosis infection. Nat Rev Immunol. 2018 Sep; 18(9):575-589.
 PubMed Abstract

Shah, JA, Musvosi, M, Shey, M, Horne, DJ, Wells, RD, Peterson, GJ, Cox, JS, Daya, M, Hoal, EG, Lin, L, Gottardo, R, Hanekom, WA, Scriba, TJ, Hatherill, M, Hawn TR. A functional TOLLIP variant is associated with BCG-specific immune responses and tuberculosis. Amer. J. Resp. Care and Critical Medicine. 2017; 96:502-511.
 PubMed Abstract

Randhawa, AK, Shey, MS, Keyser, A, Peixoto, B, Wells, RD, de Kock, M, Lerumo, L, Hughes, J, Hussey, G, Hawkridge, A, Kaplan, G, Hanekom, WA, Hawn TR, and the SATVI team. Association of Human TLR1 & TLR6 Deficiency with Altered Immune Responses to BCG Vaccination in South African Infants. PLoS Pathogens. 2011; 7:e1002174.

Thuong, NTT, Dunstan, SJ, Chau, TTH, Thorsson, V, Simmons, SP, Quyen, NTH, Thwaites, GE, Lan, NTN, Hibberd, M, Teo, YY,  Seielstad, M,  Aderem, A, Farrar, JJ and Hawn TR. Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles. PLoS Pathogens. 2008; 4:e1000229.
 PubMed Abstract

Hawn TR, Verbon, A, Lettinga, KD, Zhao, LP, Li, SS, Laws, RJ, Skerrett, SJ, Beutler, B, Schroeder, L, Nachman, A, Ozinsky, A, Smith, KD, Aderem, A. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to Legionnaires’ Disease.  J. Exp Med. 2003; 198: 1563-1572.
 PubMed Abstract