W. Conrad Liles, MD, PhD | Allergy and Infectious Diseases

Professor

Medicine

Adjunct Professor

Pathology, Pharmacology and Global Health

Co-Director, Molecular Medicine and Mechanisms of Disease (M3D) Graduate Program

Co-Director, Molecular Medicine Training Program University of Washington

Associate Chair of Medicine

Sites of Practice:

University of Washington Medical Center

Faculty Information

Biography

Dr. Liles returned to the University of Washington in 2012 from the University of Toronto, where he was Vice-Chair and Professor of Medicine, Director of the Division of Infectious Diseases, and the Canada Research Chair in Infectious Diseases and Inflammation. In addition to his duties as Professor and Associate Chair, Dr. Liles serves as Co-Director of the Molecular Medicine Training Program at the University of Washington.

Education & Training:

University of Washington

Seattle, WA

1987

PhD

University of Washington, Department of Pharmacology

Seattle, WA

1987

Residency

Massachusetts General Hospital

Boston, MA

1987-1990

Chief Residency

University of Washington Medical Center

Seattle WA

1990-1991

Fellowship, Division of Allergy & Infectious Diseases

University of Washington

Seattle, WA

1991-1994

Honors:

Elected member, Association of American Physicians (AAP)

Elected member, American Clinical and Climatological Association (ACCA)

Fellow, American College of Physicians (ACP)

Fellow, Infectious Diseases Society of America (IDSA)

Canada Research Chair in Inflammation and Infectious Diseases

2006-2012

Fialkow Scholar Award

1998

Contact

Email:

wcliles@uw.edu

Phone:

(206) 221-6965

Mailing Address:

1959 NE Pacific St.

Box 356420

Seattle, WA 98195

Research & Clinical Interests

Research Interests:

Innate immunity
Molecular pathogenesis of organ injury
Acute lung injury/ARDS
Acute kidney injury (AKI)
Endothelial cell biology
Sepsis
Malaria
Immunopathogenesis ofinfectious diseases
Phagocyte biology

Clinical Interests:

Tropical medicine
Zoonoses
Congenital immunodeficiency disorders
General infectious diseases
Immunomodulatory therapy

Publications

PubMed:

PubMed Bibliography

Publications:

Mei, SHJ, Haitsma, JJ, Santos, CC dos, Deng, Y, Lai, PFH, Slutsky, AS, Liles WC, Stewart, DJ. Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis.. Am J Respir Crit Care Med. 2010; 182(8): 1047-57.
• PubMed Abstract

Ricciuto, DR, Santos, CC dos, Hawkes, M, Toltl, LJ, Conroy, AL, Rajwans, N, Lafferty, EI, Cook, DJ, Fox-Robichaud, A, Kahnamoui, K, Kain, KC, Liaw, PC, Liles WC. Angiopoietin-1 and angiopoietin-2 as clinically informative prognostic biomarkers of morbidity and mortality in severe sepsis. Crit Care Med. 2011; 39(4): 702-10.
• PubMed Abstract

dos Santos C, Murthy S, Hu P, Shan Y, Haitsma JJ, Mei SHJ, Stewart DJ, Liles WC. Network analysis of transcriptional responses induced by mesenchymal stem cell treatment of experimental sepsis. Am J Pathol.2012; 181(5): 1681-92.
• PubMed Abstract

Lovegrove, FE, Tangpukdee, N, Opoka, RO, Lafferty, EI, Rajwans, N, Hawkes, M, Krudsood, S, Looareesuwan, S, John, CC, Liles WC, Kain, KCl. Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. PLoS One. 2009; 4(3): e4912

Lovegrove, FE, Gharib, SA, Peña-Castillo, L, Patel, SN, Ruzinski, JT, Hughes, TR, Liles WC, Kain, KC. Parasite burden and CD36-mediated sequestration are determinants of acute lung injury in an experimental malaria model. PLoS Pathog. 2008; 4(5): e1000068.
• PubMed Abstract

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