Wesley C. Van Voorhis, MD, PhD | Allergy and Infectious Diseases

Professor

Department of Medicine, Division of Allergy & Infectious Diseases

Adjunct Professor

Department of Microbiology

Adjunct Professor

Department of Global Health

Director, Center for Emerging and Re-emerging Infectious Diseases (CERID)

Sites of Practice:

University of Washington Medical Center

Faculty Information

Biography

Education & Training:

PhD, Immunology

Rockefeller University

New York NY

1976-1983

Cornell University Medical College

New York NY

1978-1984

Resident in Internal Medicine

University of California, San Francisco

San Francisco CA

1985-1986

Fellowship in Infectious Diseases

University of Washington Medical School and Fred Hutchinson Cancer Research Center

Seattle WA

1986-1989

Honors:

Research Fellowship, Center for Cancer Research, Massachusetts Institute of Technology

1976

National Science Foundation Graduate Student Fellowship

1977

Medical Scientist Training Program Fellowship

1978

Franklyn Ellenbogen Prize in Hematology/Oncology, Cornell University Medical College

1984

Alpha Omega Alpha Honor Society

1986

Award for Excellence, Medical House Officer/Teacher, University of California, San Francisco Medical School, Class of 1986

Searle Scholar Award

1989

PEW Scholar in the Biomedical Sciences Award

Research Career Development Award, NIH

1991

Elected, American Society for Clinical Investigation

1997

Councilor, Western Society for Clinical Investigation

2000-2003

Young Investigator Award, Western Society of Clinical Investigation

2001

Award from 1st Year Medical Student Class for Best Teacher of the Winter 2002 quarter

2002

Award from 1st Year Medical Student Class for Best Teacher of the Winter 2003 quarter

2003

PI of 2003 Project of Year Award from Medicines for Malaria Venture

2003

Secretary Treasurer, Western Society for Clinical Investigation

2003-2006

Elected, American Association of Physicians

2005

Chair (06-08) and Member, Training Program Directors Committee, Infectious Diseases Society of America

2003-2008

Chair, Drug Target Selection Group, Tropical Disease Research Unit, World Health Organization

2005-2012

Science in Medicine Lecturer, University of Washington

2012

President, Western Association of Physicians

2012-2013

Mayo Soley Award for Research Excellence, Western Association of Physicians

2015

Contact

Email:

wesley@uw.edu

Phone:

(206) 543-2447

Mailing Address:

750 Republican St

Box 358061

Seattle, WA 98195-8061

Research & Clinical Interests

Research Interests:

Drug discovery and development for bacterial and parasitic diseases, particularly cryptosporidium, malaria

Clinical Interests:

Travel and tropical medicine
General infectious diseases

Publications

PubMed:

PubMed Bibliography

Publications:

Ojo KK, Eastman RT, Vidadala R, Zhang Z, Rivas KL, Choi R, Lutz JD, Reid MC, Fox AMW, Hulverson MA, Kennedy M, Isoherranen N, Kim LM, Comess KM, Kempf DJ, Verlinde CLMJ, Su X-Z, Kappe S, Maly DJ, Fan E, & Van Voorhis WC. Specific inhibitor of PfCDPK4 blocks malaria transmission: Chemical-genetic validation. J Infect Dis. 2014; 209:275-84.
• PubMed Abstract

Baugh L, Gallagher LA, Patrapuvich R, Clifton MC, Gardberg AS, Edwards TE, Armour B, Begley DW, Dieterich SH, Dranow DM, Abendroth J, Fairman JW, Fox D 3rd, Staker BL, Phan I, Gillespie A, Choi R, Nakazawa-Hewitt S, Nguyen MT, Napuli A, Barrett L, Buchko GW, Stacy R, Myler PJ, Stewart LJ, Manoil C, Van Voorhis WC. Combining functional and structural genomics to sample the essential burkholderia structome. PLoS One. 2013; 8(1):e53851.
• PLoS One Abstract

Castellanos-Gonzalez A, A. White AC Jr, Ojo KK, Vidadala R, Zhang Z, Reid MC, Fox AMW, Keyloun KR, Rivas K, Irani A, Dann SM, Fan E, Maly DJ, Van Voorhis WC. A novel Calcium Dependent Protein Kinase Inhibitor as a lead compound for treating Cryptosporidiosis. J Infect. Dis. 2013; 208:1342-8.
• PubMed Abstract

Ojo KK, Pfander C, Mueller NR, Burstroem C, Larson ET, Bryan CM, Fox AM, Reid MC, Johnson SM, Murphy RC, Kennedy M, Mann H, Leibly DJ, Hewitt SN, Verlinde CL, Kappe S, Merritt EA, Maly DJ, Billker O, Van Voorhis WC. Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors. J Clin Invest. 2012; 122(6):2301-5.
• PubMed Abstract

Magarinos MP, Carmona SP, Crowther GJ, Ralph SA, Roos DA, Shanmugam D, Van Voorhis WC, Aguero F. TDR Targets: a chemogenomics resource for neglected diseases. Nucl Acids Res. 2012; 40(Database issue):D1118-27.
• PubMed Abstract

Nwaka S, Besson D, Ramirez B, Maes L, Matheeussen A, Bickle Q, Mansour NR, Yousif F, Townson S, Gokool S, Cho-Ngwa F, Samje M, Misra-Bhattacharya S, Murthy PK, Fakorede F, Paris JM, Yeates C, Ridley R, Van Voorhis WC, Geary T. Integrated Dataset of Screening Hits against Multiple Neglected Disease Pathogens. PLoS Negl Trop Dis. 2011; 5(12):e1412.
• PubMed Abstract

Engelson EJ, Buckner FS, Van Voorhis WC. An essential farnesylated kinesin in Trypanosoma brucei. PLoS One. 2011; 6(11): e26508.
• PubMed Abstract

Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, Sharlow ER, Bathurst I, El Mazouni F, Fowble JW, Forquer I, McGinley PL, Castro S, Angulo-Barturen I, Ferrer S, Rosenthal PJ, Derisi JL, Sullivan DJ, Lazo JS, Roos DS, Riscoe MK, Phillips MA, Rathod PK, Van Voorhis WC, Avery VM, Guy RK. Chemical genetics of Plasmodium falciparum. Nature. 2010; 465(7296):311-5.
• PubMed Abstract

Ojo KK, Larson ET, Keyloun KR, Castaneda LJ, Derocher AE, Inampudi KK, Kim JE, Arakaki TL, Murphy RC, Zhang L, Napuli AJ, Maly DJ, Verlinde CL, Buckner FS, Parsons M, Hol WG, Merritt EA, Van Voorhis WC. Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors. Nat Struct Mol Biol. 2010; 17:602-7.
• PubMed Abstract

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