Aspirin-exacerbated Respiratory Disease Research
We define the role of mast cells and eosinophils in the immunopathogenesis of aspirin-exacerbated respiratory disease (AERD). We also determine the effect of new biologics that target Th2 cytokine- and eosinophil-mediated responses on sinus disease control and lung function in AERD patients undergoing aspirin desensitization.
Clinical Epidemiology of Infectious Diseases
Our investigators utilize epidemiologic techniques to study the incidence, prevalence, and risk factors associated with various infections, especially STDs, HIV, sepsis, and urinary tract infections.
A hallmark of these studies is close interaction with laboratory collaborators in order to utilize molecular epidemiologic techniques or study patient materials at the molecular and cellular level.
Our clinical trials focus principally on STDs, urinary tract infections, and infections of the immunocompromised host.
Human Immunodeficiency Virus Infection (HIV)
We provide a wide range of opportunities to investigate the epidemiology, natural history, immunology, molecular virology, and clinical care of patients with HIV infection.
NIH-sponsored AIDS Clinical Trials and AIDS Vaccine Evaluation Units are located at the University of Washington, as well as a Fogarty program for international AIDS investigation and training.
We offer a wide variety of research opportunities through the Fred Hutchinson Cancer Research Center and the Seattle Cancer Care Alliance, the world's largest marrow transplant center.
Studies range from the molecular biology of viral pathogens in transplant patients, especially CMV, HSV, and HCV, to clinical studies of the epidemiology, treatment, and prevention of CMV and fungal infections.
Multiple collaborations between faculty in this track and those in the virology and immunology tracks foster interdisciplinary investigative opportunities.
Infectious Disease Immunology
We study the immunobiology and immunogenetics of host cell responses to infectious agents, especially Treponema pallidum, CMV, HIV, other retroviruses, HSV, chlamydia, and listeria.
Particular emphasis is placed on elucidating the roles of innate immunity, specific cytokines, and T cell subsets in these infections.
Leukocyte Biology and Function
We focus on the mechanisms by which phagocytes recognize and kill microorganisms, the roles of mast cells and eosinophils in allergic responses and infectious diseases, the role of apoptosis, and the role and function of phagocytes in acute inflammation and tissue injury.
Pathogenesis of Bacterial, Fungal, and Parasitic Diseases
We look at molecular studies of the virulence determinants integral to bacterial, fungal, and parasite pathogenesis.
Of special interest are mechanisms of attachment and cellular invasion in Escherichia coli, Pseudomonas aeruginosa, Group B streptococci, Salmonella, Chlamydia trachomatis, Haemophilus ducreyi, Treponema pallidum, Aspergillus fumigatus, and Candida albicansinfections.
Potential drug targets and drug development are being pursued for Trypanosoma cruzi, Trypanosoma brucei, Leishmania spp., and Plasmodium falciparum.
Pathogenesis of Viral Diseases
An integrated interdisciplinary group studies everything from basic molecular virology to immunologic aspects of viral diseases, to the clinical epidemiology, prevention, and treatment of viral diseases.
Expertise is especially concentrated in viral STDs, retroviruses, and viral infections of the immunocompromised host.
Sexually Transmitted Diseases
We offer a multi-disciplinary approach to the study of sexually transmitted infections, ranging from clinical and epidemiological studies in the United States and developing countries to molecular pathogenesis and immune responses to STD pathogens.
Organisms of particular interest include Chlamydia trachomatis, Treponema pallidum, herpes simplex virus, human papillomavirus, Haemophilus ducreyi, and Neisseria gonorrhoeae.
Our mission is to decrease the global burden of TB through high-impact scientific research that includes discovery, evaluation, and implementation of novel diagnostics and therapeutics. We also aim to foster intensive mentoring of trainees, multi-disciplinary research, and strong local and international collaborations.