Matthew C.

Altman

MD, MPhil

related links

bio

Genome transcriptional profiling and genome sequencing technologies are powerful approaches to identify novel biomarkers and mechanisms of immune mediated diseases. These technologies generate large amounts of biological information and require sophisticated computational tools to understand molecular pathways of the immune system in health and disease. Dr. Altman’s translational research interests focus on the use of whole genome transcriptional profiling and multi-omics approaches, and leverage big-data computational biology to understand the molecular mechanisms underpinning severe asthma and other immunologic diseases. Furthermore, his work seeks to develop and understand personalized approaches to the use of immune based therapeutics in these diseases. He leads and/or collaborates with several large NIAID funded consortiums, including the Childhood Asthma in Urban Settings (CAUSE) Consortium, the Inner City Asthma Consortium (ICAC), the Human Immunology Project Consortium (HIPC), the Immune Tolerance Network (ITN), the Preventing Asthma in High Risk Kids (PARK) project, and the Allergic Diseases Cooperative Research Centers (AADCRC), as well as the NIH Environmental Influences on Child Health Outcomes (ECHO) Program.

research interests

My primary research interest is applying systems biology, transcriptomics, multi-omics, and bioinformatics approaches to the study of severe asthma including the pathogenesis of asthma development and asthma exacerbations. I also use these approaches for the study respiratory viral infections, allergy, and other immunologic disorders.

clinical interests

My clinical interests are in asthma, primary immunodeficiency, and drug allergy.

education & training

MD, Harvard University, Boston, MA (2009)

MPhil, Biological Science, Cambridge University, United Kingdom (2007)

Fellowship in Allergy & Immunology, University of Washington, Seattle, WA (2012-2015)

Resident in Internal Medicine, Brigham and Women's Hospital, Boston, MA (2009-2012)

honors

Seattle Magazine Top Doctors, Allergy and Immunology, Seattle (2015-2023)

AAAAI Faculty Development Award (2019)

AAAAI Foundation and I. Leonard Bernstein, MD FAAAAI Memorial Lectureship Award (2020)

publications