William Reed

Henderson Jr.

MD

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Bio

William R. Henderson, Jr., MD is Professor of Medicine at the University of Washington where he heads the Allergy Section, Center for Allergy and Inflammation, UW Medicine at South Lake Union. He is Director of the University of Washington Allergy and Immunology Fellowship Training Program and Chief of the UWMC Allergy Clinics. He has been recognized as one of Seattle's Top Doctors by Seattle and Seattle Met magazines and one of U.S. News Top Doctors. He has authored over 125 peer-reviewed research publications in high-impact journals such as The New England Journal of Medicine and The Journal of Clinical Investigation. His research has focused on the production of biochemical molecules that cause asthma and other allergic disorders with the goal to develop new therapies for these diseases. He has served as Chair of the American Board of Allergy and Immunology and on the Board of Directors of the American Academy of Allergy, Asthma and Immunology and the scientific advisory boards of ICOS Corporation and Gilead Sciences. He is an executive committee member of the Seattle Food Allergy Consortium (SeaFAC). Dr. Henderson is a member of the American Society of Clinical Investigation and the Association of American Physicians

Research interests

• Immunopathogenesis of Allergic and Immunologic Disorders 
• Translational Research of Allergic and Immunologic Disorders
• Asthma Research (Severe Asthma, Aspirin-induced Asthma
• Chronic Urticaria Research
• Food Allergy Research

Clinical interests

Honors

Chair, American Board of Allergy & Immunology 2003

Seattle Magazine Top Doctors, Allergy & Immunology 2010-2012

Seattle Met Magazine Top Doctors, Allergy & Immunology 2011

Seattle Magazine Top Doctors, Allergy & Immunology 2014-2017

Seattle Met Magazine Top Doctors, Allergy & Immunology 2016

Seattle Met Magazine Top Doctors, Allergy, Asthma & Immunology 2017

Publications

Lai Y, Altemeier WA, Vandree J, Piliponsky AM, Johnson B, Appel CL, Frevert CW, Hyde DM, Ziegler SF, Smith DE, Henderson WR Jr, Gelb MH, Hallstrand TS. Increased density of intraepithelial mast cells in exercise-induced bronchoconstriction regulated via epithelial-derived TSLP and IL-33. J Allergy Clin Immunol. 2013 Nov 9; pii: S0091-6749(13)01473-5. doi: 10.1016/j.jaci.2013.08.052. [Epub ahead of print]
• PubMed Abstract

Henderson WR Jr, Ye X, Lai Y,et al. Key role of group V secreted phospholipase A2 in Th2 cytokine and dendritic cell-driven airway hyperresponsiveness and remodeling. PLoS One. 2013; 8:e56172.
• PubMed Abstract

Banerjee ER, Laflamme MA, Papayannopoulou T, Kahn M, Murry CE, Henderson WR Jr. Human embryonic stem cells differentiated to lung lineage-specific cells ameliorate pulmonary fibrosis in a xenograft transplant mouse model. PLoS One. 2012; 7:e33165.
• PubMed Abstract

Henderson WR Jr, Chi EY, Ye X, et al. Inhibition of Wnt/β-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci USA. 2010; 107:14309-14. 
• PubMed Abstract

Hallstrand TS, Wurfel MM, Lai Y, Ni Z, Gelb MH, Altemeier WA, Beyer RP, Aitken ML, Henderson WR. Transglutaminase 2, a novel regulator of eicosanoid production in asthma revealed by genome-wide expression profiling of distinct asthma phenotypes. PLoS One. 2010; 5: e8583.
• PubMed Abstract

Henderson WR Jr, Chi EY, Bollinger JG, et al. Importance of group X secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model. J Exp Med. 2007; 204:865-77.
• PubMed Abstract

Peters-Golden M, Henderson WR Jr. Leukotrienes. N Engl J Med. 2007; 357:1841-54.
• PubMed Abstract