Michael J.

Boeckh

MD

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bio

Dr. Boeckh heads a clinical research program focused on infectious diseases in immunocompromised patients. He conducts laboratory research, observational studies, as well as clinical trials of all phases.

research interests

Dr. Boeckh's major areas of interest are cytomegalovirus (CMV), HHV-6, respiratory viruses, and the genetic basis of infectious diseases. Most of these projects are bench-to-clinic translational research. Dr. Boeckh's lab is focused on pathogen-specific immune reconstitution. One major area of research is CMV, including the immune reconstitution after transplantation, transmission of CMV, and disease management in the immunocompromised patient population. Recently, he also initiated studies to determine the role of CMV and HHV-6 reactivation in the outcome of immunocompetent patients with sepsis and acute lung injury.

Another active area of research is in respiratory viruses. Studies in immunocompromised patients are focused on the association of respiratory viruses and airflow obstruction, the adaptive immune response to respiratory viruses, viral dissemination and gene expression signatures as biomarkers for disease severity, and management strategies. Recently, he has initiated studies to examine viral dynamics in immunocompetent patients.

education & training

MD, Freie Universität, Berlin, Germany (1985)

PhD, Medicine, Freie Universität, Berlin, Germany (1988)

Internship and Residency in Internal Medicine, Klinikum Steglitz, University Hospital, Freie Universität, Berlin, Germany (1986-1989)

Fellow in Infectious Diseases, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, WA (1990-1992)

honors

Recipient Clemens Memorial Lecture and Award, NIAID Collaborative Antiviral Study Group

Best Doctors (Washington Magazine)

publications

Seo S, Renaud C, Kuypers J, Chiu C, Huang ML, Samayoa E, Xie H, Yu G, Fisher CE, Gooley TA, Miller S, Hackman RC, Myerson D, Sedlak RH, Kim YJ, Fukuda T, Fredricks DN, Madtes DK, Jerome KR, Boeckh M.  Idiopathic pneumonia syndrome after hematopoietic cell transplantation: evidence of occult infectious etiologies. Blood. 2015 Jun 11; 125(24):3789-97.
• PubMed Abstract

Hill JA, Sedlak RH, Zerr DM, Huang ML, Yeung C, Myerson D, Jerome KR, Boeckh M. Prevalence of chromosomally integrated human herpesvirus 6 in patients with human herpesvirus 6-central nervous system dysfunction. Biol Blood Marrow Transplant. 2015 Feb; 21(2):371-3.
• PubMed Abstract

Waghmare A, Campbell AP, Xie H, Seo S, Kuypers J, Leisenring W, Jerome KR, Englund JA, Boeckh MJ. Respiratory syncytial virus lower respiratory disease in hematopoietic cell transplant recipients: viral RNA detection in blood, antiviral treatment, and clinical outcomes. Clin Infect Dis. December 2013; 57(12):1731-41. 
• PubMed Abstract

Marty FM, Winston DJ, Rowley SD, Vance E, Papanicolaou GA, Mullane KM, Brundage TM, Robertson AT, Godkin S, Momméja-Marin H, Boeckh MJ. CMX001-201 Clinical Study Group. CMX001 to prevent cytomegalovirus in hematopoietic-cell transplantation.  N Engl J Med.September 2013; 369(13): 1227-36.
• PubMed Abstract

Green ML, Leisenring WM, Xie H, Walter RB, Mielcarek M, Sandmaier BM, Riddell SR, Boeckh MJ. CMV reactivation after allogeneic HCT and relapse risk: evidence for early protection in acute myeloid leukemia. Blood. August 2013; 122(7):1316-24
• PubMed Abstract

Bochud PY, Chien WJ, Marr K, Leisenring WM, Upton A, Janer M, Rodrigues SD, Li S, Aderem A, Boeckh M. Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation. New Engl J Med. 2008; 359(17):1766-77.
• PubMed Abstract