Thomas R.
Hawn
MD, PhD
related links
bio
Tom’s laboratory examines why individuals have different susceptibility to infections and whether these insights can lead to novel treatment and vaccine strategies. Studies include examining the functional and clinical significance of human variation in the innate immune system and its regulation of susceptibility to tuberculosis and other infections. His laboratory defines and characterizes the cellular function of genetic polymorphisms in innate immune response genes and the mechanisms of how they regulate susceptibility to human infection with an overall goal of elucidating novel therapeutic strategies.
research interests
- Tuberculosis
- Mycobacterial Diseases (Leprosy, MAC)
- Innate Immunity
- Pulmonary Immunity
clinical interests
- Tuberculosis
- Mycobacterial Diseases
- HIV
- General Infectious Disease
honors
UW Dept of Medicine’s Philip and Helen Fialkow Award (2008)
Burroughs Wellcome Fund Clinical Scientist Award in Translational Research (2009-2015)
American Society of Clinical Investigation (2011)
UW Dept Medicine Housestaff Research Mentorship Award (2013)
publications
Simmons JD, Stein CM, Seshadri C, Campo M, Alter G, Fortune S, Schurr E, Wallis RS, Churchyard G, Mayanja-Kizza H, Boom WH, Hawn TR. Immunologic mechanisms of human resistance to persistent Mycobacterium tuberculosis infection. Nat Rev Immunol. 2018 Sep; 18(9):575-589.
• PubMed Abstract
Shah, JA, Musvosi, M, Shey, M, Horne, DJ, Wells, RD, Peterson, GJ, Cox, JS, Daya, M, Hoal, EG, Lin, L, Gottardo, R, Hanekom, WA, Scriba, TJ, Hatherill, M, Hawn TR. A functional TOLLIP variant is associated with BCG-specific immune responses and tuberculosis. Amer. J. Resp. Care and Critical Medicine. 2017; 96:502-511.
• PubMed Abstract
Randhawa, AK, Shey, MS, Keyser, A, Peixoto, B, Wells, RD, de Kock, M, Lerumo, L, Hughes, J, Hussey, G, Hawkridge, A, Kaplan, G, Hanekom, WA, Hawn TR, and the SATVI team. Association of Human TLR1 & TLR6 Deficiency with Altered Immune Responses to BCG Vaccination in South African Infants. PLoS Pathogens. 2011; 7:e1002174.
• Article
Thuong, NTT, Dunstan, SJ, Chau, TTH, Thorsson, V, Simmons, SP, Quyen, NTH, Thwaites, GE, Lan, NTN, Hibberd, M, Teo, YY, Seielstad, M, Aderem, A, Farrar, JJ and Hawn TR. Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles. PLoS Pathogens. 2008; 4:e1000229.
• PubMed Abstract
Hawn TR, Verbon, A, Lettinga, KD, Zhao, LP, Li, SS, Laws, RJ, Skerrett, SJ, Beutler, B, Schroeder, L, Nachman, A, Ozinsky, A, Smith, KD, Aderem, A. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to Legionnaires’ Disease. J. Exp Med. 2003; 198: 1563-1572.
• PubMed Abstract