This is unpublished


Infectious Diseases
Adjunct Associate Professor, Global Health
Associate Professor Medicine - Division of Allergy & Infectious Disease
Adjunct Associate Professor, Lab Medicine and Pathology
Affiliate Investigator Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center
Sites of Practice
Harborview Medical Center
University of Washington Medical Center

related links


Dr. Seshadri's research focuses on the human immune response to Mycobacterium tuberculosis, the bacteria responsible for tuberculosis. By better understanding what factors are responsible for protective immunity, he hopes to contribute to ongoing efforts to develop an effective vaccine. Specifically, his work addresses two questions:

  • What is the role of T-cells that respond to lipids and small molecules produced by bacteria?
  • Why do some people fail to convert their tuberculin skin tests despite frequent and close contact with tuberculosis patients?

research interests

  • Tuberculosis
  • Immunology

clinical interests

  • General medicine
  • General infectious diseases
  • Tuberculosis

education & training

MD, New Jersey Medical School, Newark NJ (2001)

Internship and Residency in Internal Medicine, Duke University Medical Center, Durham NC (2001-2004)

Clinical and Research Fellow in Infectious Diseases, Massachusetts General Hospital, Boston MA (2005-2009)

Senior Fellowship in Infectious Diseases, University of Washington School of Medicine, Seattle WA (2009-2010)


Alpha Omega Alpha (AOA) Medical Honors Society, UMDNJ -New Jersey Medical School (2000)

Infectious Disease Society of Washington Fellow Research Award and Presentation (2010)

Chair of Medicine Scholars Award (2013)

American Society of Clinical Investigation –Young Physician Scientist Award (2014)



Yu KK, Fischinger S, Smith MT, Atyeo C, Cizmeci D, Wolf CR, Layton ED, Logue JK, Aguilar MS, Shuey K, Loos C, Yu J, Franko N, Choi RY, Wald A, Barouch DH, Koelle DM, Lauffenburger D, Chu HY, Alter G, Seshadri C. Comorbid illnesses are associated with altered adaptive immune responses to SARS-CoV-2. JCI Insight. 2021 Mar 22;6(6):e146242. doi: 10.1172/jci.insight.146242. PMID: 33621211 

Layton ED, Barman S, Wilburn DB, Yu KKQ, Smith MT, Altman JD, Scriba TJ, Tahiri N, Minnaard AJ, Roederer M, Seder RA, Darrah PA, Seshadri C. T Cells Specific for a Mycobacterial Glycolipid Expand after Intravenous Bacillus Calmette-Guérin Vaccination. J Immunol. 2021 Mar 15;206(6):1240-1250. doi: 10.4049/jimmunol.2001065. Epub 2021 Feb 3. PMID: 33536255

James CA, Seshadri C. T Cell Responses to Mycobacterial Glycolipids: On the Spectrum of "Innateness".  Front Immunol. 2020 Feb 11;11:170. doi: 10.3389/fimmu.2020.00170. eCollection 2020. PMID: 32117300