Dr. Shah's research focuses on understanding the molecular pathways that contribute to tuberculosis disease. He conducts studies of host genetics and their impact on tuberculosis susceptibility and immune responses, then develops small animal models of susceptibility genes and alleles to define novel targets to improve tuberculosis vaccines and develop novel host-directed treatments for tuberculosis.
In addition to his own research work funded by an R01 as Principal Investigator, Dr. Shah is a Co-Investigator on the Systems Genetics of Tuberculosis program grant, and studies the effects of pregnancy on human immune responses to Mycobacterium tuberculosis. Additionally, he is a Co-investigator on the Veterans Affairs EPIC3 study, which is a longitudinal evaluation of clinical characteristics, immune responses, and epideimology of the COVID-19 epidemic in Veterans across 19 different sites, which has enrolled over 3000 participates for monitoring over two years after enrollment.
Dr. Shah trained in the laboratory of Robert Seder at the NIH, where he contributed to understanding the cellular and molecular effects of novel vaccine adjuvants against intracellular infections, and performed his postfellowship research work in the laboratory of Thomas Hawn developing his understanding of host genetics of tuberculosis susceptibility, developing collaborations in Vietnam, Nepal, South Africa, and Brazil.
- Host genetic studies of tuberculosis immune responses and susceptibility
- Developing small animal models that recapitulate human genetic susceptibility against tuberculosis
- Effects of pregnancy on tuberculosis pathogenesis
- Understanding mycobacterial granuloma immune structures
- General infectious diseases
- Tuberculosis and non-tuberculous mycobacterial infection
education & training
BA, University of Chicago (1999)
MD, University of Chicago Pritzker School of Medicine (2005)
Intern, Department of Medicine, University of Washington, Seattle, WA (2005-2006)
Resident, Department of Medicine, University of Washington, Seattle, WA (2006-2008)
Chief Resident, Harborview Medical Center, Seattle, WA (2008-2009)
Fellow, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA (2009-2013)
IDSA IDWeek Trainee Abstract Award 2013
Federation of Clinical Immunology Societies Trainee Award 2014
American Association of Immunologists Trainee Abstract Award 2016
University of Washington Department of Medicine Scholars Award 2016
Early Career Scientist Award, Committee on Tuberculosis Vaccine Discovery, Bill and Melinda Gates Foundation 2017
Practitioner Lead in Quality and Safety, VA Puget Sound Healthcare System (Inaugural Award) 2021
HeRO Award, given to VA Puget Sound Infection Prevention Team, National Nominee, Department of Veterans’ Affairs 2021
Sigma Xi Honor Society 2022