Matthew C.

Altman

MD, MPhil

related links

bio

Genome transcriptional profiling and genome sequencing technologies are powerful approaches to identify novel biomarkers and mechanisms of immune mediated diseases. These technologies generate large amounts of biological information and require sophisticated computational tools to understand molecular pathways of the immune system in health and disease. Dr. Altman’s translational research interests focus on the use of whole genome transcriptional profiling and multi-omics approaches, and leverage big-data computational biology to understand the molecular mechanisms underpinning severe asthma and other immunologic diseases. Furthermore, his work seeks to develop and understand personalized approaches to the use of immune based therapeutics in these diseases. He leads and/or collaborates with several large NIAID funded consortiums, including the Childhood Asthma in Urban Settings (CAUSE) Consortium, the Inner City Asthma Consortium (ICAC), the Human Immunology Project Consortium (HIPC), the Immune Tolerance Network (ITN), the Preventing Asthma in High Risk Kids (PARK) project, and the Allergic Diseases Cooperative Research Centers (AADCRC), as well as the NIH Environmental Influences on Child Health Outcomes (ECHO) Program.

research interests

My primary research interest is applying systems biology, transcriptomics, multi-omics, and bioinformatics approaches to the study of severe asthma including the pathogenesis of asthma development and asthma exacerbations. I also use these approaches for the study respiratory viral infections, allergy, and other immunologic disorders.

clinical interests

My clinical interests are in asthma, primary immunodeficiency, and drug allergy.

education & training

MD, Harvard University, Boston, MA (2009)

MPhil, Biological Science, Cambridge University, United Kingdom (2007)

Fellowship in Allergy & Immunology, University of Washington, Seattle, WA (2012-2015)

Resident in Internal Medicine, Brigham and Women's Hospital, Boston, MA (2009-2012)

honors

Seattle Magazine Top Doctors, Allergy and Immunology, Seattle (2015-2023)

AAAAI Faculty Development Award (2019)

AAAAI Foundation and I. Leonard Bernstein, MD FAAAAI Memorial Lectureship Award (2020)

publications

Altman MC, Gill MA, Whalen E, Babineau DC, Shao B, Liu AH, Jepson B, Gruchalla RS, O'Connor GT, Pongracic JA, Kercsmar CM, Khurana Hershey GK, Zoratti EM, Johnson CC, Teach SJ, Kattan M, Bacharier LB, Beigelman A, Sigelman SM, Presnell S, Gern JE, Gergen PJ, Wheatley LM, Togias A, Busse WW, Jackson DJ. Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children. Nat Immunol. 2019 May; 20(5):637-651.
• PubMed Abstract

Altman MC, Whalen E, Togias A, O’Connor GT, Bacharier LB, Bloomberg GR, Kattan M, Wood RA, Presnell S, Le Beau P, Jaffee K, Visness CM, Busse WW, Gern JE. Allergen induced activation of NK cell genes represents an early life immune response in development of allergic asthma. J Allergy Clin Immunol. 2018 Dec; 142(6):1856-1866.
• PubMed Abstract

Altman MC, Reeves SR, Parker AR, Whalen E, Misura KMS, Comeau M, James RG, Hallstrand TS, Ziegler SF, Debley JS. Type I interferon response by RSV-infected pediatric asthmatic bronchial epithelial cells is inversely correlated with pulmonary function. J Allergy Clin Immunol. 2018 Aug; 142(2):451-459.
• PubMed Abstract

Altman MC, Busse WW. A Deep Dive into Asthma Transcriptomics: Lessons from UBIOPRED. Am J Resp Crit Care Med. 2017 May 15; 195(10):1279-1280.
• PubMed Abstract

Altman MC, Lenington J, Bronson S, Ayars AG. Combination Omalizumab and Mepolizumab Therapy for Refractory Allergic Bronchopulmonary Aspergillosis (ABPA). J Allergy Clin Immunol Pract. 2017 Jul-Aug; 5(4):1137-1139.
• PubMed Abstract

Vodovotz Y, Xia A, Read E, Bassaganya-Riera J, Hafler DA, Sontag E, Wang J, Tsang JS, Day JD, Kleinstein S, Butte AJ, Altman MC, Hammond R, Benoist C, Sealfon SC. Solving Immunology? Trends Immunol. 2017 Feb; 38(2):116-127.
• PubMed Abstract

Alsina L, Israelsson E, Altman MC, Dang KK, Ghandil P, Israel L, von Bernuth H, Baldwin N, Qin H, Jin Z, Banchereau R, Anguiano E, Ionan A, Abel L, Puel A, Picard C, Pascual V, Casanova JL, Chaussabel D. A narrow repertoire of transcriptional modules responsive to pyogenic bacteria is impaired in patients carrying loss-of-function mutations in MYD88 or IRAK4. Nat Immunol. 2014 Dec; 15(12):1134-42.
• PubMed Abstract

Altman MC, Naimi DR. Omalizumab for chronic urticaria. N Engl J Med. 2013 Jun 27; 368(26):2528-30.
• PubMed Abstract

Carroll J, Altman MC, Fearnley IM, Walker JE. Identification of membrane proteins by tandem mass spectrometry of protein ions. Proc Natl Acad Sci USA. 2007 Sep 4; 104(36):14330-5.
• PubMed Abstract