The Hybiske laboratory is broadly interested in the interactions between intracellular pathogens and host cells. The lab is particularly interested in the pathways used by intracellular organisms to exit host cells. This research encompasses the underlying molecular mechanisms of these processes and the illumination of how these strategies facilitate unique interactions with the host immune system, most notably for immune evasion.
A major research focus in the lab is to decipher the mechanisms by which the intracellular pathogens Chlamydia and malaria manipulate cellular function in order to exit host cells and cause infectious disease. Collectively, diseases caused by Chlamydia and malaria are the among the most devastating and widespread to plague mankind; effective intervention strategies are sorely lacking. And remarkably, these two disparate pathogens have coevolved similar mechanisms for escaping their respective host cells and disseminating within human hosts. Our ultimate goal is to leverage a thorough understanding of these pathogenic mechanisms as a new, unexplored therapeutic platform.
For additional information, please visit http://www.hybiskelab.org
The Hybiske Lab investigates the molecular mechanisms of Chlamydia pathogenesis, including sexually transmitted infections. Our ultimate goals are to identify new therapeutic targets against this major pathogen, and to contribute to our broader understanding of the pathogenic mechanisms of intracellular bacteria. Current research projects include:
- Mechanisms of Chlamydia exit from host cells, dissemination, and immune evasion
- Functional genomics for Chlamydia
- Virulence factor discovery for Chlamydia
- Proteomic discovery of novel Chlamydia-host interactions
Education & Training:
PhD, Molecular and Cell Biology, University of California, Berkeley CA (2003)
Postdoctoral fellow, University of California, Berkeley CA (2003)
Postdoctoral fellow, University of California, San Francisco WA (2003-2005)
Postdoctoral fellow, University of California, Berkeley CA (2005-2008)
Predoctoral fellowship award, California Tobacco-Related Disease Research Program (1999-2002)
NIAID Young Investigator Award (2010)
Top Ten Reviewer for Cellular Microbiology (2013)
Chin E, Kirker K, Zuck M, James G, Hybiske K. Actin recruitment to the Chlamydia inclusion is spatiotemporally regulated by a mechanism that requires host and bacterial factors. PLoS ONE. 2012; 7(10):e46949.
• PLOS One Abstract
Hybiske K, Stephens RS. Exit strategies of intracellular pathogens. Nature Reviews Microbiol. 2008; 6:99-110.
• PubMed Abstract
Hybiske K, Stephens RS. Mechanisms of host cell exit by the intracellular bacterium Chlamydia. Proc Natl Acad Sci USA. 2007; 104:11430-11435.
• PNAS Abstract
Hybiske K, Stephens RS. Entry mechanisms of Chlamydia trachomatis into non-phagocytic cells. Infect Immun. 2007; 75:3925-3934.
• PubMed Abstract