Dr. Chu’s research is focused on preventive interventions against influenza, RSV and emerging respiratory viruses, such as SARS-CoV-2. Dr. Chu conducts clinical-translational research on large-scale community-based studies of respiratory viruses, with a focus on vaccines, antivirals, and diagnostics. She is also interested in defining clinical and immune correlates of protection against respiratory viruses and describing mechanisms of maternal-fetal immunity against respiratory viruses.
Dr. Chu is a Multiple Principal Investigator of the Seattle Flu Study, which first identified COVID-19 community transmission in the United States, Co-Investigator on the University of Washington Vaccine Trials and Evaluation Unit (VTEU), and Site Principal Investigator for the ACTT-1 trial, which evaluated Remdesivir for the treatment of COVID-19. Over the last four months, Dr. Chu’s lab has enrolled a prospective observational cohort of 300 COVID-19 inpatients and outpatients to study immune responses over time.
Her previous work includes describing transmission patterns of RSV, rhinovirus, and human metapneumovirus, the epidemiology and adverse birth outcomes associated with respiratory viral pneumonia in pregnant women, and the kinetics of transplacental RSV antibody transfer and decay in infants. Dr. Chu has also performed clinical trials of vaccine candidates in both domestic and international sites, including Nepal and Bangladesh.
- Epidemiology of respiratory viruses
- Defining clinical and immune correlates of protection against respiratory viruses
- Molecular characterization of respiratory viruses in diverse settings
- Investigating large-scale community transmission patterns of respiratory viruses
- Describing mechanisms of maternal-fetal immunity against respiratory viruses
- Vaccine and antiviral development
- General infectious diseases
- Viral respiratory infectious diseases
- Internal Medicine.
Education & training
- BA, Cornell University, Oxford University (2001)
- MD, Duke University, Durham, NC (2005)
- Intern, Department of Medicine, Harvard University, Boston, MA (2005-2006)
- Resident, Department of Medicine, Harvard University, Boston, MA (2006-2008)
- Fellow, Division of Allergy & Infectious Diseases, University of Washington, Seattle,WA (2009-2013)
- MPH, Immunology, University of Washington, Seattle, WA (2012)
- American Society of Clinical Investigation Young Physician Scientist Award 2017
- Infectious Disease Society of America Young Investigator Award in Vaccine Development 2016
- University of Washington Chair of Medicine Scholars Award 2015
- Macrae Foundation Respiratory Virus Symposium Early Investigator Award 2015
- Thrasher Early Career Award 2011
- Washingtonian of the Year, Washington State Leadership Board 2020
- Researcher of the Year, Health Care Leadership Awards 2020
- Spotlight Award, Seattle National Organization for Women 2020
Chu HY, Englund JA, Starita LM, Famulare M, Brandstetter E, Nickerson DA, Rieder MJ, Adler A, Lacombe K, Kim AE, Graham C, Logue J, Wolf CR, Heimonen J, McCulloch DJ, Han PD, Sibley TR, Lee J, Ilcisin M, Fay K, Burstein R, Martin B, Lockwood CM, Thompson M, Lutz B, Jackson M, Hughes JP, Boeckh M, Shendure J, Bedford T. Early Detection of Covid-19 through a Citywide Pandemic Surveillance Platform. N Engl J Med. 2020 May 1; PubMed PMID: 32356944; PubMed Central PMCID: PMC7206929.
Seydoux E, Homad LJ, MacCamy AJ, Parks KR, Hurlburt NK, Jennewein MF, Akins NR, Stuart AB, Wan YH, Feng J, Whaley RE, Singh S, Boeckh M, Cohen KW, McElrath MJ, Englund JA, Chu HY, Pancera M, McGuire AT, Stamatatos L. Analysis of a SARS-CoV-2-Infected Individual Reveals Development of Potent Neutralizing Antibodies with Limited Somatic Mutation. Immunity. 2020 Jul 14;53(1):98-105.e5. doi: 10.1016/j.immuni.2020.06.001. Epub 2020 Jun 8. PMID: 32561270; PMCID: PMC7276322.
Atyeo, C, Fischinger S, Zohar T, Slein M, Burke J, Loos C, McCulloch DJ, Newman KL, Wolf C, Shuey K, Ryan E, Charles R, Schimdt A, Suscovich TJ, Linde C, Chen B, Lauffenburger D, Chu HY*, Alter G*, Distinct serological signatures track with SARS-CoV-2 outcome, Immunity, In Press